Table 2.

Observed value (mean ± SD) of intraocular pressure (mmHg), pulse rate (per minute), systolic blood pressure (mmHg), diastolic blood pressure (mmHg) and mean arterial pressure (mmHg) in groups 1 and 2, and their respective mean difference (for each parameter) between both treatment groups at baseline and follow-up visits.

Time	IOP			PR			SBP			DBP			MAP
	G1	G2	Δ	G1	G2	Δ	G1	G2	Δ	G1	G2	Δ	G1	G2	Δ
0 W	23.40 ± 1.83	23.35 ± 1.55	0.06	81.23 ± 9.66	80.50 ± 10.29	0.73	129.69 ± 13.57	128.96 ± 14.67	0.73	82.92 ± 6.43	82.08 ± 6.50	0.85	98.51 ± 8.33	97.71 ± 8.92	0.80
2 W	18.73 ± 1.73	18.60 ± 1.71	0.13	79.48 ± 7.36	74.79 ± 6.22	4.69**	128.69 ± 12.58	125.65 ± 12.81	3.04	82.65 ± 7.51	81.73 ± 7.43	0.92	98.00 ± 8.12	96.37 ± 8.58	1.63
4 W	18.10v1.36	17.73 ± 1.29	0.37	79.96 ± 7.19	74.15 ± 6.65	5.81**	127.88 ± 11.69	126.73 ± 10.24	1.15	82.96 ± 8.20	81.58 ± 7.75	1.39	97.94 ± 8.36	96.63 ± 7.98	1.31
8 W	17.64 ± 1.35	17.17 ± 1.12	0.47	79.83 ± 7.26	72.62 ± 6.32	7.21**	127.08 ± 9.07	126.12 ± 11.95	0.96	82.92 ± 8.20	81.69 ± 7.24	1.23	97.64 ± 7.88	96.50 ± 8.13	1.14
12W	16.85 ± 1.18	16.23 ± 1.29	0.62*	80.37 ± 7.01	71.29 ± 5.08	9.08**	127.81 ± 10.20	126.62 ± 11.59	1.19	83.54 ± 8.00	81.54 ± 7.38	2.00	98.29 ± 7.92	96.56 ± 8.27	1.73

DBP, diastolic blood pressure; FDC, fixed-dose combination; G1, travoprost monotherapy; G2, timolol/brinzolamide; IOP, intraocular pressure; MAP, mean arterial; pressure; PR, pulse rate; SBP, systolic blood pressure; W, week; Δ, mean difference in respective parameter between groups 1 and 2.

^*p < 0.05; **p < 0.001 mean difference in parameter between two groups.