Table 1.
Tryptophan and kynurenine pathway metabolites in plasma after 14 days of 0.9% TTP diet in C57BL/6 male mice (n = 6)
| Control | 0.9% TTP | ||
|---|---|---|---|
| Mean ± SD | Mean ± SD | P -value | |
| Trp (μM) | 114.9 ± 5.92 | 144.4 ± 1.81 | 0.0147 |
| Kyn (μM) | 1.2 ± 0.02 | 1.3 ± 0.01 | 0.0346 |
| Neopt (nM) | 1.7 ± 0.10 | 2.1 ± 0.21 | 0.2182 |
| AA (nM) | 138.5 ± 7.84 | 83.5 ± 4.96 | 0.0069 |
| HAA (nM) | 21.8 ± 5.06 | 7.7 ± 0.24 | 0.0490 |
| KA (nM) | 150.9 ± 29.0 | 48.3 ± 5.19 | 0.0406 |
| XA (nM) | 147.3 ± 21.0 | 34.3 ± 0.48 | 0.0095 |
| HK (nM) | 86.3 ± 29.6 | 44.3 ± 14.0 | 0.1410 |
| QA (nM) | 291.0 ± 24.3 | 223.5 ± 48.8 | 0.3410 |
| Nam (μM) | 2.60 ± 0.37 | 4.49 ± 0.19 | 0.0160 |
Abbreviations: AA Anthranilic acid, HAA 3-hydroxyanthranilic acid, HK 3-hydroxykynurenine, KA Kynurenic acid, Kyn Kynurenine, Neopt Neopterin, Nam Nicotinamide, QA Quinolinic acid, Trp Tryptophan, XA Xanthurenic acid