Table 2.
Correlation between clinicopathological variables and ADAR expression and CNV in Gastric cancer patients
| variable | ADAR expression | P value | ADAR amplification | P value | ||
|---|---|---|---|---|---|---|
| High(17) | Low(25) | Yes(18) | No(24) | |||
| Age (year) | ||||||
| ≥ 66a | 11 | 14 | 0.573 | 11 | 14 | 0.856 |
| < 66 | 6 | 11 | 7 | 10 | ||
| Gender | ||||||
| Male | 11 | 15 | 0.758 | 12 | 14 | 0.582 |
| Female | 6 | 10 | 6 | 10 | ||
| Pathological N category | ||||||
| N0 | 1 | 1 | 0.074 | 1 | 1 | 0.086 |
| N1 | 1 | 4 | 0 | 5 | ||
| N2 | 5 | 15 | 8 | 12 | ||
| N3 | 10 | 5 | 9 | 6 | ||
| M classification | ||||||
| M0 | 6 | 19 | 0.008* | 7 | 18 | 0.018* |
| M1 | 11 | 6 | 11 | 6 | ||
| Site of primary tumor | ||||||
| Antrum | 4 | 6 | 0.937 | 4 | 6 | 0.315 |
| Body | 8 | 13 | 9 | 12 | ||
| Cardia | 4 | 4 | 5 | 3 | ||
| Fundus | 1 | 2 | 0 | 3 | ||
| Histology | ||||||
| Well differentiated | 0 | 5 | 0.015* | 1 | 4 | 0.143 |
| Moderately differentiated | 3 | 11 | 4 | 10 | ||
| Poorly differentiated | 10 | 8 | 9 | 9 | ||
| Undifferentiated | 4 | 1 | 4 | 1 | ||
| Size of primary tumor | ||||||
| < 6.1 | 7 | 21 | 0.004* | 8 | 20 | 0.008* |
| ≥ 6.1 | 10 | 4 | 10 | 4 | ||
| Tumor stage | ||||||
| Stage 4 | 11 | 6 | 0.008* | 11 | 6 | 0.018* |
| Stage 3 | 6 | 19 | 7 | 18 | ||
| Lymphovascular invasion | ||||||
| Present | 14 | 16 | 0.196 | 15 | 15 | 0.139 |
| Absent | 3 | 9 | 3 | 9 | ||
* indicates p-value < 0.05. a the median age at surgery was 66 years