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. 2020 Apr 17;9(4):999. doi: 10.3390/cells9040999

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Western blot analysis of protein expression levels (A) and their integrity (B,C) in control and irradiated MCF7 and U2OS cells. (A) Blot cuts showing signals of intact proteins. Note, reduction of SUN2 protein and near absence of H3K9me3 epigenetic modification in senescent cells (7 days post irradiation). (B,C) Reactivity of antibodies against nesprin-1 (B) and SUN2 (C) proteins on the whole blots. Note, significant fragmentation of intact nesprin-1 (250 kDa band) and SUN2 (85 kDa band) in irradiated cells.