Table 5.

Multivariate Cox proportional hazard analysis of clinicopathological features and immunological markers with disease-free survival (DFS) and overall survival (OS) in 63 patients with LA-NPC at the time of presentation

	DFS			OS
	HR	95% CI	*P	HR	95% CI	P
Age
< 40 years	1			1
≥ 40 years	0.7	0.2–2.6	0.624	1.3	0.1–32.3	0.839
WHO type
III	1			1
I & II	1.5	0.4–4.8	0.516	0.2	0.0–1.3	0.094
UICC Stage
III	1
IVa	1.4	0.4–4.8	0.597	0.6	0.1–5.6	0.604
CD3+ TIL
High	1			1
Low	8	2.5–30.6	< 0.001	17.5	2.1–434.0	0.006
FOXP3+/CD3+ TIL
Low (≤ 10% of CD3 + TIL)	1			1
High (> 10% of CD3 + TIL)	1.1	0.4–2.8	0.889	1.8	0.3–18.7	0.564
⋄ PD-1+/CD3+ TIL
Low (<  10% of CD3 + TIL)	1
High (≥ 10% of CD3 + TIL)	0.6	0.2–1.7	0.331	0.2	0–1.5	0.117
PD-L1
Positive (≥ 10%)	1
Negative (<  10%)	1.3	0.4–3.8	0.672	5.6	1–49.6	0.054

*P values in bold represent significant data. ⋄Three samples had unknown PD-1 status. ║ mem = membranous, cyto = cytoplasmic