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. 2020 May 14;18:75. doi: 10.1186/s12951-020-00629-y

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — Representation of the nanoparticle and radiotherapy in systemic antitumor immunity. Three types of NPs (BNP, ANPs and PLGA-R837/Cat) combined with radiotherapy can promote the tumor associated antigen secretion, anti-tumor cytokines secretion and systemic immunity. The function of NPs not only stimulated the DCs and T cells activation, but also suppressed the tumor malignant immune cells such as Tregs and macrophages