Table 2.

Research questions- tobacco use

For people with SMD who use tobacco, are pharmacological (including nicotine replacement therapy, bupropion, varenicline) and/or non-pharmacological interventions effective to support tobacco cessation? Population/ Intervention / Comparison / Outcome (PICO) Population: People with SMD who use tobacco Intervention: • Pharmacological interventions: including nicotine replacement therapy (NRT), bupropion, varenicline • Non-pharmacological interventions Comparison: care as usual and/or placebo Outcomes: • Critical o Tobacco cessation/abstinence rates o Tobacco consumption rates o Respiratory disease outcomes (COPD, asthma) • Important: o Frequency of adverse events/side-effects