Table 3.

Research questions- substance (drug and/ or alcohol) use disorders

For people with SMD and substance (drug and/or alcohol) use disorder, are pharmacological and/or non-pharmacological interventions for substance use disorder effective to support reduction in substance use-related outcomes? Population/ Intervention / Comparison / Outcome (PICO) Population: people with SMD and substance (drug and/or alcohol) use disorder Intervention: pharmacological and/or non-pharmacological interventions for substance use disorders: - Pharmacological interventions - Non-pharmacological interventions: e.g. motivational interviewing and/or CBT, psychoeducation, brief assessment interview, dual-focus interventions Comparison: care as usual / placebo or one treatment vs another Outcomes: Critical - Level of consumption - Frequency of use - Abstinence - Relapse rates Important: - Frequency of adverse events / side-effects