Distribution of cumulative burden of grades 3 to 5 chronic health conditions in the St. Jude Lifetime Cohort Study of childhood cancer survivors and community controls. X-axis shows age in years. Abbreviations: ALL, acute lymphoblastic leukemia; AML acute myeloid leukemia; CNS, central nervous system tumors; NHL, non-Hodgkin lymphoma; STS, soft tissue sarcomas. From Bhakta et al., Lancet 2017.