Table 2.

Rate of Immunoglobulin A Deficiency in a Pediatric-Onset Obsessive-Compulsive Disorder Compared with Other Pediatric Populations and Adult Obsessive-Compulsive Disorder

	N	IgA deficient (N)	IgA deficient (%)	Odds ratioa	p-Value	95% CI
Total sample
OCD	206	31	15	—	—	—
TS	157	18	11	1.37	0.32	0.73–2.55
Celiac disease	624	85	14	1.12	0.61	0.72–1.75
ADHD	534	69	13	1.19	0.45	0.76–1.89
ASD	524	44	8	1.93	<0.01	1.18–3.16
Anxiety	1206	99	8	1.98	<0.01	1.28–3.06
Male
OCD	107	19	18	—	—	—
TS	112	10	9	1.89	0.06	0.97–4.99
Celiac disease	240	31	13	1.46	0.24	0.78–2.71
ADHD	389	39	10	1.94	0.03	1.07–3.52
ASD	414	35	8	2.75	<0.01	1.23–4.28
Anxiety	488	45	9	2.13	0.01	1.19–3.81
Female
OCD	99	12	12	—	—	—
TS	45	8	18	0.64	0.37	0.24–1.69
Celiac disease	384	54	14	0.84	0.62	0.43–1.65
ADHD	145	21	14	0.81	0.60	0.38–1.74
ASD	110	9	8	1.55	0.35	0.62–3.85
Anxiety	718	54	8	1.79	0.12	0.87–3.30
Adult
OCD adult-onset	1042	64	6	2.71	<0.001	1.71–4.28

^aOdds ratio of IgA deficiency in pediatric OCD cohort compared with indicated comparison cohort.