TABLE 1.

FDA-approved host-directed antiviral agents^a

Trade name	Generic name	Target virus	Mechanism of action	Yr
Intron A	IFN-α-2b	HPV	IFN mediated	1988
Alferon N injection	IFN-α-N3	HPV	IFN mediated	1989
Condylox	Podofilox	HPV	Interrupts cell division cycle	1990
Intron A	IFN-α-2b	HCV	IFN mediated	1991
Intron A	IFN-α-2b	HBV	IFN mediated	1992
Infergen	Interferon alfacon-1	HCV	IFN mediated	1997
Aldara	Imiquimod	HPV	Induction of cytokines	1997
Rebetron	PegIFN-α-2b plus ribavirin	HCV	IFN mediated	1998
Rebetol	Ribavirin	HCV	Multiple modes of action	1998
Pegintron/Sylatron	PegIFN-α-2b	HCV	IFN mediated	2001
Pegasys	PegIFN-α-2a	HCV	IFN mediated	2002
Pegasys	PegIFN-α-2a	HBV	IFN mediated	2005
Veregen	Sinecatechins	HPV	Immunomodulator	2006
Selzentry	Maraviroc	HIV-1	Blocks gp120 and CCR5 interaction	2007

^aIFN, interferon; HBV, hepatitis B virus; HCV, hepatitis C virus; HIV-1, human immunodeficiency virus type 1; HPV, human papillomavirus; PegIFN-α, pegylated IFN-α.