Fig 6.

TMPRSS2 gene expression is higher in nasal epithelial cells from type 2 (T2)-high participants with allergy. In data set GSE19187, participants with asthma and/or allergic rhinitis demonstrate increased nasal epithelial expression of TMPRSS2 compared with that demonstrated by healthy participants regardless of whether the allergy and asthma groups were combined (∗P = .0022) (A) or evaluated as separate groups (∗P = .018 for the paired comparison; ^†P = .034) (B). C, The T2-high participants demonstrate significantly higher expression of TMPRSS2, whereas the expression of TMPRSS2 by T2-low participants is similar to that demonstrated by healthy participants. ∗P = .0012 for the paired comparison. Box plots show medians with interquartile ranges. CA, Rhinitis with controlled asthma; NA, rhinitis and no asthma; UA, rhinitis with uncontrolled asthma.