Table 1.

Toxicity possibly or probably related to treatment with enzastaurin (N = 22)

Toxicity	Grade 1-2	Grade 3-4	Grade 5
Thrombocytopenia	6 (27%)	5 (23%)	0
QTc prolongation	5 (23%)	2 (9%)*	0
Elevated AST	9 (41%)	0	0
Elevated ALT	5 (23%)	1	0
Intracranial hemorrhage	0	0	1†
Hypermagnesemia	1	0	0
Proteinuria	1	0	0
Hematuria	1	0	0
Nausea	1	0	0

Abbreviations: AST, aspartate aminotransferase; ALT, alanine aminotransferase.

^*Cases were transient, asymptomatic, and required no intervention or therapy.

^†Occurred in the setting of grade 3 thrombocytopenia.