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. 2019 Oct 31;16(3):673–683. doi: 10.1080/21645515.2019.1669414

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© 2019 Instituto Butantan. Published with license by Taylor & Francis Group, LLC.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.

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Figure 5. — Increased immune response induced in the lungs of BALB/c mice immunized with rBCG-LTAK63 after 3 months.

Cytokine production was analyzed in the lungs of BALB/c mice 3 months after s.c. immunization with BCG or rBCG-LTAK63 (1 x 10⁶ CFU). A total of 2 × 10⁵ cells was stimulated with Mtb extract for 24 h or 48 h and the supernatants were analyzed by multiplex cytokine assays (IL-2, IL-17 and IL10 at 24 h; IFN-γ, TNF-α and IL-6 at 48 h). The results represent one of two independent experiments with similar results (n = 4–5 animals per group). Statistical significance was determined by one-way ANOVA. Significant differences were observed for the indicated groups (* P < .05; ** P < .01; *** P < .001).