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. 2019 Oct 30;16(3):664–672. doi: 10.1080/21645515.2019.1671134

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© 2019 The Author(s). Published with license by Taylor & Francis Group, LLC.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.

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Figure 1. — Humoral immune response and protective effect of the G+ CsA vaccine in mice after priming neonates and boosting in infancy. (A) Neonatal mice were immunized at day 0 (5 days after birth) and day 14 then challenged intranasally with RSV at day 28. The mice were sacrificed at day 33. (B) Individual lung tissue RSV load was assessed by qRT-PCR and expressed as % of the load found in the PBS control group (unvaccinated infection control). (C) Serum anti-G IgG antibody titer was tested by ELISA. (D) Serum RSV-neutralizing antibody was tested by plaque assay. Data are mean ± SEM of n = 4–6 mice per group. ND, no detection. *P < .05, **P < .01, ***P < .001, ****P < .0001.