Table 2.
Summary of anti-HBs responses: persistence analysis set.
| Post-infant |
Post-toddler |
Persistence |
|||||
|---|---|---|---|---|---|---|---|
| Schedule | Parameter | DTaP5-HB-IPV-Hib | DTaP3-HB-IPV/Hib | DTaP5-HB-IPV-Hib | DTaP3-HB-IPV/Hib | DTaP5-HB-IPV-Hib | DTaP3-HB-IPV/Hib |
| 3 + 1 | n | 162 | 165 | 186 | 186 | Group 1: 191 | Group 2: 189 |
| % ≥10 mIU/mL | 98.8 | 97.0 | 100.0 | 100.0 | 70.2 | 82.0 | |
| (95% CI) | (95.6, 99.9) | (93.1, 99.0) | (98.0, 100.0) | (98.0, 100.0) | (63.1, 76.5) | (75.8, 87.2) | |
| % ≥100 mIU/mL | 79.6 | 84.2 | 96.8 | 98.4 | 18.3 | 39.7 | |
| (95% CI) | (72.6, 85.5) | (77.8, 89.4) | (93.1, 98.8) | (95.4, 99.7) | (13.1, 24.6) | (32.7, 47.0) | |
| GMC, EU/mL | 230 | 271 | 3085 | 4157 | 24.4 | 51.3 | |
| (95% CI) | (190, 278) | (225, 326) | (2529, 3762) | (3403, 5077) | (19.5, 30.6) | (40.2, 65.5) | |
| 2 + 1 | n | 104 | 110 | 124 | 131 | Group 3: 181 | Group 4: 190 |
| % ≥10 mIU/mL | 99.0 | 98.2 | 100 | 100 | 65.7 | 83.7 | |
| (95% CI) | (94.8, 100) | (93.6, 99.8) | (97.1, 100) | (97.2, 100) | (58.3, 72.6) | (77.6, 88.6) | |
| % ≥100 mIU/mL | 80.8 | 86.4 | 97.6 | 97.7 | 17.7 | 45.3 | |
| (95% CI) | (71.9, 87.8) | (78.5, 92.2) | (93.1, 99.5) | (93.5, 99.5) | (12.4, 24.0) | (38.0, 52.6) | |
| GMC, EU/mL | 255 | 450 | 2413 | 4271 | 19.4 | 71.0 | |
| (95% CI) | (199, 327) | (348, 580) | (1946, 2992) | (3334, 5470) | (15.5, 24.4) | (54.9, 91.8) | |
Anti-HBs, anti-hepatitis B surface antigen; CI, confidence interval; EU, ELISA units; GMC, geometric mean concentration; IU, international units.