Table 3.
Summary of pertussis antibodies persistence (responses rate) following a 2 + 1 schedule: persistence analysis set.
| Group 3 |
Group 4 |
||||||
|---|---|---|---|---|---|---|---|
| Antibody | Concentration Endpointb | N | n (%) | 95% CIa | N | n (%) | 95% CIa |
| Anti-PT | ≥LLOQb | 178 | 104 (58.4) | 50.8, 65.8 | 188 | 78 (41.5) | 34.4, 48.9 |
| ≥2xLLOQ | 72 (40.5) | 33.2, 48.1 | 41 (21.8) | 16.1, 28.4 | |||
| ≥4xLLOQ | 26 (14.6) | 9.8, 20.7 | 7 (3.7) | 1.5, 7.5 | |||
| Anti-FHA | ≥LLOQ | 173 | 140 (80.9) | 74.3, 86.5 | 188 | 166 (88.3) | 82.8, 92.5 |
| ≥2xLLOQ | 81 (46.8) | 39.2, 54.5 | 133 (70.7) | 63.7, 77.1 | |||
| ≥4xLLOQ | 45 (26.0) | 19.7, 33.2 | 85 (45.2) | 38.0, 52.6 | |||
| Anti-PRN | ≥LLOQ | 180 | 119 (66.1) | 58.7, 73.0 | 190 | 138 (72.6) | 65.7, 78.8 |
| ≥2xLLOQ | 79 (43.9) | 36.5, 51.5 | 97 (51.1) | 43.7, 58.4 | |||
| ≥4xLLOQ | 28 (15.6) | 10.6, 21.7 | 35 (18.4) | 13.2, 24.7 | |||
| Anti-FIM | ≥LLOQ | 177 | 167 (94.4) | 89.9, 97.3 | 183 | 6 (3.3) | 1.2, 7.0 |
| ≥2xLLOQ | 156 (88.1) | 82.4, 92.5 | 4 (2.2) | 0.6, 5.5 | |||
| ≥4xLLOQ | 123 (69.5) | 62.1, 76.2 | 2 (1.1) | 0.1, 3.9 | |||
aConfidence intervals were calculated based on the exact binomial method of D. Collett.15
bLower limit of quntification (LLOQ) = 4 EU/mL for PT, PRN, and FIM; LLOQ = 3 EU/mL for FHA.
CI, confidence interval; FHA, filamentous hemagglutinin; FIM, fimbriae; PRN, pertactin; PT, pertussis toxin.