Figure 3.

A review of applied computational methods for designing vaccines. Illustration showing various computational tools that help in the development of a vaccine. The antibodyomics tools modify the antibody to enhance binding to the antigen. Codon optimization tools such as Codon Optimization Online (COOL), OPTIMIZER, and Codon Wizard optimize the codon for enhanced gene expression. Epimatrix and TEPITOPE SYFPEITHI are scaffolding and epitope prediction tools. Modeling tools such as CHARMm, MacroModel, and MOIL are used for modeling the structure of the protein.