Table 3.
Examples of third generation (DNA) vaccine candidates against CL associated with protection.
| SPECIES | GENE | OLD WORLD OUTCOME | NEW WORLD OUTCOME | REFERENCE |
|---|---|---|---|---|
| L. major | GP63 | Protection | Not tested | 131 |
| L. major | LACK | Protection | Not tested | 106 |
| L. amazonensis | A2 | Protection (L. chagasi) | Protection (L. amazonensis) | 133 |
| L. major | TSA | Protection | Not tested | 134 |
| L. major | H3, H4 | Partial protection | Not tested | 136 |
| L. infantum | H2A, H2B, H3, H4 | Protection against L. major | Protection against L. braziliensis | 134 |
| L. major | KMP11+ HASPB | Protection | Not tested | 146 |