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. 2020 May 7;14:438. doi: 10.3389/fnins.2020.00438

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Copyright © 2020 Nie, Sun, Zhen, Guo, Ye, Liu, Yang and Zhang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Clusters of miRNA expression and enriched pathways. (A) Heatmap of differentially expressed miRNAs of six clusters. Down, miRNAs with expression of log₂(AD/NC) or log₂(PD/NC) < -1; NA, miRNAs with expression of -1 < log₂(AD/NC) or log₂(PD/NC) < 1; Up, miRNAs with expression of log₂(AD/NC) or log₂(PD/NC) > 1. (B) KEGG pathway of miRNAs from four clusters. Target genes of miRNAs were predicted by miRanda, TargetScan, and RNAhybrid individually. Joint target genes were selected and KEGG pathway enrichment analysis was carried out. Top three pathways of each cluster were shown. The size of the dots represents the -log₁₀(p-value) of each pathway.