Table 1.
Details of vaccines and vaccinations discussed in the manuscript
| Study name | Vaccination regimen (schedule in weeks) | Vaccine inserts | Age range (Years) | Week of challenge initiation | Challenge virus used | Max No of challenges | Route & dose of challenge |
|---|---|---|---|---|---|---|---|
| M14 (n=10) | D-40L D-40L MM (0,8,16,24) | SIVmac239 Gag, Prt, RT and Env, CD40L with DNA | 3 to 6 | 48 | SIVmac251 | 8 | Intra Rectal, 6.47×10^2 TCID50 |
| P165 (n=33) | DDMM or D-GM D-GM MM (0,8,16,32) | SIVmac239 Gag, Prt, RT and Env; and GM-CSF with DNA in some animals | 3 to 17 | 57 | SIVsmE660-ABL (SIVsmE660 Hirsch 2000) | 12 | Intra Rectal, 4.12×10^2 TCID50 |
| M15 (17) | DDMM or D-GM D-GM MM (0,8,16,24) | SIVmac239 Gag, Prt, RT and Env; and GM-CSF with DNA in some animals | 3 to 19 | 48 | SIVsmE660-ABL (SIVsmE660 Hirsch 2000) | 12 | Intra Vaginal, 10.2×10^3 TCID50 |
| M19 (15) | DDMMM (0,8,16,24,38) | SIVmac239 Gag, Prt, RT and HIV 1086c Env | 4 to 15 | 58 | SHIV1157 ipd3N4 | 8 | Intra Vaginal, 4.5×10^5 TCID50 |
D, DNA (3mg/dose, intramuscular); D-GM, DNA co-expressing macaque GM-CSF (3mg/dose, intramuscular); M, MVA (1×108 pfu/dose, intramuscular).