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. Author manuscript; available in PMC: 2020 Jul 1.
Published in final edited form as: Nat Catal. 2019 Dec 2;3(1):23–29. doi: 10.1038/s41929-019-0384-6

Fig. 1.

Fig. 1.

Overview of proposed approach to CuH-catalyzed cascade reductive of difunctionalization of alkynes. A, General depiction of classical CuH reactivity in hydrofunctionalization of simple alkynes and alkenes. B, C, Design of CuH-catalyzed cascade process for alkyne 1,1-difunctionalization and potential pitfalls. D, Key precedent of CuH-catalyzed hydroamination of alkenylBdan. E, Commercial drugs containing an α-aminoboronate.