Fig. 2.

Discovery and evaluation of CuH cascade process.A, Reaction optimization. B, Substrate scope. (see Supplementary Information Section 1.3.2)

^aReaction conditions for optimization experiments: 1a (0.2 mmol), 2a (0.24 mmol), 3 (0.24 mmol), PMHS (0.4 mmol), LiO^tBu (0.4 mmol), CuBr (5 mol%), and ligand (6 mol%) in THF (1.0 mL) at room temperature for 16 h. nd = not determined. ^bIsolated yield. ^cThe enantioselectivity was determined by SFC analysis. ^dHBPin instead of HBdan. ^eNaO^tBu as the base. ^fKO^tBu as the base. ^gPMHS (2.5 equiv) and LiO^tBu (3.125 equiv). ^hUsing PMHS (3.0 equiv) and LiO^tBu (3.75 equiv).