Table 2.
Lung Physiology Data at 2, 6 (Treatment Completion) and 18 Months (One Year After Treatment Completion)
| n=43 | Baseline | 2 Months | 6 Months | 18 Months | |||||
|---|---|---|---|---|---|---|---|---|---|
| Median | (IQR) | Median | (IQR) | Median | (IQR) | Median | (IQR) | ||
| FEV1 (L) | 1.97 | (1.50–2.76) | 2.27 | (1.68 −2.89) | 2.39 | (1.80–2.92) | 2.52 | (1.95–3.04) | |
| FEV1 (%pred.) | 0.59 | (0.50–0.77) | 0.73 | (0.55–0.86) | 0.75 | (0.59–0.87) | 0.79 | (0.64–0.89) | |
| FVC (L) | 2.49 | (1.90–3.02) | 2.82 | (2.22–3.44) | 2.88 | (2.30–3.54) | 3.05 | (2.54–3.59) | |
| FVC (%pred.) | 0.63 | (0.54–0.73) | 0.74 | (0.57–0.84) | 0.77 | (0.62–0.87) | 0.81 | (0.66–0.88) | |
| FEV1/FVC (%) | 81.9 | (75.2–88.1) | 81.6 | (76.2–89.0) | 81.5 | (75.3–88.2) | 87.6 | (75.4–89.9) | |
| TLC (%pred.) | – | – | 85.84 | (72.40–93.76) | 86.76 | (78.17–100.12) | 97.97 | (83.96–110.69) | |
| IC (%pred.) | – | – | 82.05 | (68.78–97.72) | 83.67 | (64.01–106.23) | 88.16 | (70.00–112.21) | |
| FRC (%pred.) | – | – | 89.53 | (67.39–106.47) | 97.15 | (78.63–116.88) | 105.43 | (86.00–128.60) | |
| RV (%pred.) | – | – | 132.62 | (97.73–156.62) | 132.78 | (102.01–164.17) | 158.29 | (111.66–210.65) | |
| RV/TLC (%) | – | – | 38.3 | (32.5–46.8) | 37.2 | (32.5–47.9) | 40.9 | (35.4–50.0) | |
| IC/TLC ratio | – | – | 46.9 | (41.3–53.3) | 45.4 | (35.1–50.8) | 42.5 | (36.7–46.5) | |
| DLco (%pred.)a | – | – | 66.98 | (51.42–76.46) | 61.68 | (52.29–73.48) | 65.31 | (52.33–77.05) | |
| DLco/VA (%pred.) | – | – | 92.13 | (83.73–103.02) | 89.44 | (80.32–101.20) | 90.99 | (75.67–100.35) | |
| Six-minute walk distance (m) | 510 | (465–545) | 510 | (480–555) | 529 | (480–570) | 520 | (480–600) | |
| SGRQ – Total Score | |||||||||
| Mean (SD) | - | - | - | - | 6.7 | (11.0) | 2.9 | (9.9) | |
| Median (IQR) | - | - | - | - | 1.0 | (0.00–12.3) | 0.00 | (0.00–0.4) | |
| SGRQ – Activity Score | |||||||||
| Mean (SD) | - | - | - | - | 14.0 | (25.9) | 3.5 | (15.5) | |
| Median (IQR) | - | - | 0.0 | (0.0–24.4) | 0.0 | (0.0–0.0) | |||
Notes: Plethysmography and diffusing capacity were not performed prior to 2 months due to risk to staff. St. George’s Respiratory Questionnaire (SGRQ) was only performed from 6 months, as it is only validated for chronic symptoms. aFor diffusing capacity measurements, n=42.
Abbreviations: IQR, interquartile range; SD, standard deviation; FEV1, forced vital capacity in 1 sec; FVC, forced vital capacity; TLC, total lung capacity; IC, inspiratory capacity; FRC, functional residual capacity; RV, residual volume; DLco, diffusing capacity for carbon monoxide; VA, alveolar volume; L, liters; %pred., percentage of predicted; m, meters; SGRQ, St. George’s Respiratory Questionnaire.