Table 3.
Quantitative Computed Tomography Values for Subjects with Scans Performed at 2, 6 (Treatment Completion) and 18 Months (One Year After Treatment Completion)
| n=20 | 2 Months | 6 Months | 18 Months | Change 2 to 6 Months | Change 6 to 18 Months | Change 2 to 18 Months | |||
|---|---|---|---|---|---|---|---|---|---|
| Median | (IQR) | Median | (IQR) | Median | (IQR) | P-valuec | P-valuec | P-valuec | |
| TLC (L) | 3.91 | (3.14–4.44) | 4.01 | (3.39–4.57) | 4.06 | (3.46–4.69) | 0.01 | 0.99 | 0.16 |
| RV (L) | 1.89 | (1.58–2.36) | 1.79 | (1.56–2.19) | 1.96a | (1.65–2.19) | 0.41 | 0.86 | 0.77 |
| LAA (%b) | 9.07% | (4.57–11.04) | 8.76% | (6.78–11.63) | 9.84% | (7.75–14.45) | 0.20 | 0.11 | 0.02 |
| GTS (%b) | 5.26% | (2.79–9.16) | 6.85% | (4.23–10.98) | 7.13%a | (4.79–15.87) | 0.19 | 0.04 | 0.02 |
| QLF (%) | 2.15% | (1.31–3.41) | 1.14% | (0.72–1.67) | 0.76% | (0.57–1.55) | <0.01 | 0.11 | <0.01 |
| QLF (mL) | 84.67 | (63.50–139.12) | 38.30 | (31.51–69.51) | 30.48 | (21.85–72.13) | <0.01 | 0.07 | <0.01 |
Notes: an=19. bPercentage of total lung volume. cP-value for paired Wilcoxon test.
Abbreviations: TLC, total lung capacity; RV, residual volume; LAA, low-attenuation areas on inspiratory scan (ie,<-950HU, emphysema score); GTS, gas-trapping score on expiratory scan (ie, <-856HU); QLF, quantity of lung fibrosis; L, litres; mL, milliliters.