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. 2020 May 11;12:3301–3310. doi: 10.2147/CMAR.S243490

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© 2020 Li et al.

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Chemotherapy-related prognostic value of 15-mRNA signature in CRC patients. (A) The Kaplan–Meier method was used to estimate the OS of integrated early-stage cohort (N=694) using the 15-mRNA signature, stratified by adjuvant chemotherapy status; (B) Multivariate Cox proportional hazards regression analysis of CRC patients in stages I–III (N=417). Multivariables included the risk score, age at the time of diagnosis, sex, T stage, N stage, anatomical location of primary tumor, adjuvant chemotherapy and mutation status in KRAS and BRAF genes. Risk score, T stage, N stage were taken as continuous variables into account, while other factors were as categorical variables. Solid tetragonums represent the HR of death, and open-ended horizontal lines represent 95% CIs. All P-values were calculated by using Cox regression analysis.