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. 2020 May 15;15(5):e0233163. doi: 10.1371/journal.pone.0233163

Fig 6. INPP4B deficiency and HFD effect on steroid hormone metabolism.

Fig 6

A) Schematic diagram for hypothalamic–pituitary–gonadal hormonal axis and testosterone synthesis in testis. Key enzymes of the steroidogenic pathway are shown; corresponding genes showing different level of expression in mutant animals or on HFD are double-circled. B) Expression of genes in the steroidogenic pathway analyzed by qRT-PCR. The expression level for all genes was normalized to 18S. *p<0.05, ***p<0.001; n = 7/group. Data shown as mean ± SEM. Statistical analysis was performed using 2-way ANOVA.