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. 2020 May 15;15(5):e0232146. doi: 10.1371/journal.pone.0232146

Fig 1. Responder patient treated with ingenol mebutate gel for a grade II actinic keratosis on the forehead (sample AK6).

Fig 1

A: Clinical appearance of the lesion. B: Dermoscopic image showing background erythema and yellow scales with keratotic follicular openings. C: 750×750 μm confocal image at the stratum corneum showing marked hyperkeratosis. D: 750×750 μm confocal image at stratum spinosum demonstrating diffuse atypia of the keratinocytes with different sizes and shapes of the cells. E-F: Clinical and dermoscopic clearance of the lesion after ingenol mebutate treatment. G-H: 750×750 μm confocal images showing normal appearance of the skin.