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. 2020 May 15;15(5):e0232146. doi: 10.1371/journal.pone.0232146

Fig 3. Constructed protein-protein interaction network of 388 downregulated genes in post-treatment versus pre-treatment actinic keratosis samples that responded to ingenol mebutate gel.

Fig 3

Nodes represent proteins and different line intensities denote the type of evidence for the interaction. Statistical analysis results for the network: number of nodes: 388, number of edges: 715; average node degree: 3.69; average local clustering coefficient: 0.418; expected number of edges: 317; PPI enrichment p-value < 1E-16.