Table 2.

Cytokine concentrations [pg/mL ($\text{mean}\pm \text{standard}$ error)] in brain homogenates of adult offspring.

Region	Sex	Exposure	$\text{IFN}\mathrm{\gamma }$	IL-4	IL-6	IL-2
Neocortex	Male	FA	$0.397\pm 0.05$	$0.215\pm 0.07$	$0.831\pm 0.25$	$3.519\pm 0.67$
		PG/VG	$0.428\pm 0.12$	$0.202\pm 0.07$	$0.870\pm 0.23$	$3.598\pm 0.50$
		$+\text{Nic}$	$0.360\pm 0.14$	$0.215\pm 0.13$	$0.740\pm 0.35$	$3.568\pm 0.46$
	Female	FA	$0.413\pm 0.07$	$0.251\pm 0.06$	$0.907\pm 0.16$	$3.382\pm 0.52$
		PG/VG	$0.391\pm 0.10$	$0.233\pm 0.10$	$0.853\pm 0.26$	$3.343\pm 0.71$
		$+\text{Nic}$	$0.366\pm 0.09$	$0.242\pm 0.11$	$0.789\pm 0.22$	$3.140\pm 0.78$
Diencephalon	Male	FA	$0.430\pm 0.03$	$0.266\pm 0.03$	$1.175\pm 0.23$	$4.183\pm 0.36$
		PG/VG	$0.375\pm 0.03$*	$0.134\pm 0.03$	$0.890\pm 0.46$	$4.187\pm 0.85$
		$+\text{Nic}$	$0.320\pm 0.03$**	$0.159\pm 0.03$**	$1.003\pm 0.45$	$3.966\pm 1.21$
	Female	FA	$0.411\pm 0.03$	$0.209\pm 0.04$	$1.142\pm 0.32$	$4.277\pm 0.28$
		PG/VG	$0.344\pm 0.03$*	$0.173\pm 0.04$	$1.105\pm 0.33$	$4.654\pm 0.79$
		$+\text{Nic}$	$0.258\pm 0.03$**	$0.095\pm 0.04$**	$0.789\pm 0.31$	$3.980\pm 0.77$
Hippocampus	Male	FA	$0.672\pm 0.09$	$0.264\pm 0.11$	$0.762\pm 0.37$	$3.071\pm 0.67$
		PG/VG	$0.588\pm 0.04$	$0.256\pm 0.11$	$0.970\pm 0.38$	$2.629\pm 0.93$
		$+\text{Nic}$	$0.623\pm 0.09$	$0.274\pm 0.15$	$0.954\pm 0.48$	$2.653\pm 1.18$
	Female	FA	$0.747\pm 0.08$	$0.263\pm 0.12$	$0.893\pm 0.61$	$2.948\pm 0.71$
		PG/VG	$0.688\pm 0.10$	$0.293\pm 0.14$	$0.901\pm 0.46$	$2.877\pm 0.65$
		$+\text{Nic}$	$0.549\pm 0.07$**	$0.251\pm 0.14$	$0.955\pm 0.57$	$2.352\pm 1.31$
Cerebellum	Male	FA	$0.620\pm 0.05$	$0.154\pm 0.06$	$0.551\pm 0.13$	$2.986\pm 0.95$
		PG/VG	$0.624\pm 0.05$	$0.176\pm 0.06$	$1.059\pm 0.13$*	$3.741\pm 1.07$
		$+\text{Nic}$	$0.660\pm 0.05$	$0.160\pm 0.06$	$0.869\pm 0.12$	$3.840\pm 1.88$
	Female	FA	$0.712\pm 0.05$	$0.205\pm 0.08$	$0.627\pm 0.13$	$3.548\pm 0.67$
		PG/VG	$0.691\pm 0.05$	$0.205\pm 0.07$	$0.898\pm 0.12$*	$3.427\pm 0.88$
		$+\text{Nic}$	$0.608\pm 0.05$	$0.168\pm 0.08$	$0.764\pm 0.12$	$3.918\pm 1.58$

Note: FA, filtered air; IFN, interferon; IL, interleukin; PG/VG, propylene glycol/vegetable glycerin; $+\text{Nic}$, propylene glycol/vegetable glycerin plus nicotine.

^*$p<0.05$ compared with FA-exposed offspring.

^**$p<0.01$ compared with FA-exposed offspring.