TABLE 2.
Summary of PiB‐PET and AV‐1451‐PET biomarkers, mean (SD), by regionally defined PiB status
| PiB‐negative (n = 84) | PiB‐positive (n = 34) | P | Total sample (n = 118) | |
|---|---|---|---|---|
| Global PiB SUVR | 1.12 (0.05) | 1.58 (0.33) | <0.0001 | 1.25 (0.27) |
| AV‐1451 SUVR Braak 1/2 | 1.15 (0.11) | 1.25 (0.14) | 0.001 | 1.18 (0.13) |
| AV‐1451 SUVR Braak 3/4 | 1.11 (0.07) | 1.18 (0.07) | <0.0001 | 1.13 (0.08) |
| AV‐1451 SUVR Braak 5/6 | 1.02 (0.07) | 1.07 (0.07) | 0.0002 | 1.03 (0.07) |
Note: Participants were classified as regionally PiB‐positive if at least one of nine composite regions exceeded the corresponding regional cutoff, including anterior cingulate, posterior cingulate, insula, superior frontal cortex, orbitofrontal cortex, lateral temporal cortex, parietal cortex, precuneus, and ventral striatum. (See Methods for details and SUVR cutoff values.)