TABLE 4.

Standardized regression estimates reflecting association effect size between traditional neuropsychological tests and PET biomarkers

	Global PiB SUVR	AV‐1451 SUVR Braak 1/2	AV‐1451 SUVR Braak 3/4	AV‐1451 SUVR Braak 5/6
MMSE	−0.03 [−0.2, 0.14]	−0.19 [−0.36, −0.02]	−0.15 [−0.32, 0.02]	−0.14 [−0.31, 0.04]
Logical Memory IR	−0.06 [−0.23, 0.12]	−0.07 [−0.26, 0.11]	−0.01 [−0.19, 0.17]	0.02 [−0.16, 0.20]
Logical Memory DR	0.02 [−0.16, 0.20]	−0.03 [−0.23, 0.16]	0.01 [−0.17, 0.20]	0.07 [−0.12, 0.25]
Semantic fluency	−0.07 [−0.25, 0.11]	−0.1 [−0.27, 0.09]	−0.08 [−0.25, 0.1]	−0.01 [−0.19, 0.17]
Trail Making Test A	0.04 [−0.15, 0.22]	0.07 [−0.12, 0.26]	0.06 [−0.13, 0.24]	−0.01 [−0.19, 0.18]
Trail Making Test B	−0.005 [−0.18, 0.17]	−0.06 [−0.23, 0.12]	−0.07 [−0.24, 0.1]	0.01 [−0.17, 0.18]
Clock drawing	0.08 [−0.11, 0.27]	−0.09 [−0.28, 0.1]	−0.01 [−0.19, 0.18]	0.05 [−0.14, 0.24]
Processing speed composite scorea	−0.02 [−0.19, 0.16]	−0.04 [−0.22, 0.13]	−0.05 [−0.22, 0.12]	−0.03 [−0.20, 0.15]
Global composite scoreb	−0.04 [−0.22, 0.13]	−0.09 [−0.28, 0.09]	−0.06 [−0.24, 0.12]	−0.03 [−0.21, 0.15]

Note: Standardized estimates are adjusted for age, sex, race, and education; standardized partial coefficients can be interpreted as the number of SDs the outcome increases (cognitive measure) for every SD increase in the predictor (PET measure), holding all other predictors constant. Bolded estimates are those whose 95% CI does not contain zero, consistent with P < .05.

DR = delayed recall; MMSE = Mini Mental State Exam.

^aComponent measures = Trail Making Tests A and B, semantic fluency.

^bComponent measures = all NP tests listed in Table.