Table 5.
Summary of key zebrafish toxicity data.
| Compound | Class | DevTox assay phenotype | Ref | DNT assay phenotype | Ref |
|---|---|---|---|---|---|
| ADONA | Polyfluoroether | Negativea | This study | Negativea | This study |
| GenX Free Acid | Branched polyfluoroether | Negativea | This study | Negativea | This study |
| PFESA1 | Branched polyfluoroether | Negativea | This study | Negativea | This study |
| PFHxA | Aliphatic carboxylic acid | Negative | This study; Truong et al. 2014 | Hyperactivitya | This study |
| PFOA | Aliphatic carboxylic acid | Negative | This study; Padilla et al. 2012; Truong et al. 2014 | Negative | This study; Khezri et al. 2017 |
| Positive | Hagenaars et al. 2011; Jantzen et al. 2016; Ulhaq et al. 2013a | Hyperactivity | Ulhaq et al. 2013b | ||
| PFBS | Aliphatic sulfonic acid | Negative | This study; Truong et al. 2014 | Negativea | This study |
| Positive | Hagenaars et al. 2011; Ulhaq et al. 2013a | Hyperactivity | Ulhaq et al. 2013b | ||
| PFPeS | Aliphatic sulfonic acid | Positivea | This study | Hyperactivitya | This study |
| PFHxS | Aliphatic sulfonic acid | Positive | This study; Truong et al. 2014 | Hyperactivitya | This study |
| Negative | Khezri et al. 2017 | ||||
| PFHpS | Aliphatic sulfonic acid | Positivea | This study | Hyperactivitya | This study |
| PFOS | Aliphatic sulfonic acid | Positive | This study; Hagenaars et al. 2011; Huang et al. 2010; Jantzen et al. 2016; Padilla et al. 2012; Truong et al. 2014; Ulhaq et al. 2013a, 2013b | Hyperactivity | This study; Huang et al. 2010; Khezri et al. 2017; Spulber et al. 2014 |
| Hypoactivity | Ulhaq et al. 2013b |
Note: Data on PFAS evaluated in the present study and previous work. ADONA, 4,8-dioxa-3H-perfluorononanoate; DevTox, developmental toxicity; DNT, developmental neurotoxicity; GenX Free Acid, perfluoro-2-propoxypropanoic acid; PFBS, perfluorobutanesulfonic acid; PFESA1, perfluoro-3,6-dioxa-4-methyl-7-octene-1-sulfonic acid; PFHpS, perfluoroheptanesulfonic acid; PFHxA, perfluorohexanoic acid; PFHxS, perfluorohexanesulfonic acid; PFOA, perfluoro-n-octanoic acid; PFOS, perfluorooctanesulfonic acid; PFPeS, perfluoropentaslufonic acid; Ref, reference.
a
Indicates previously unreported findings.