Figure 1.

Experimental setup, survival, and blood hemoglobin analysis of wild-type (WT) and steroid and xenobiotic receptor knockout (SXRKO) mice exposed to polychlorinated biphenyl 153 (PCB-153) or vehicle. (A) Exposure schematic for perinatal and chronic exposure to PCB-153; number of mice per group are reported as ($n=\text{number}$ of mice for perinatal study; number of mice for chronic study). (B) Survival of WT or SXRKO mice exposed to PCB-153 or vehicle [dimethylsulfoxide (DMSO)] in chronic exposure study; both cohorts of SXRKO mice exposed to PCB-153 are shown independently (cohort 1, $n=16$; cohort 2, $n=11$); all other groups are shown as the sum of both cohorts (WT DMSO, $n=14$; WT PCB, $n=23$; SXRKO DMSO, $n=18$) and merged together in one bold red line. (C) Hemoglobin measurements of SXRKO mice exposed to DMSO ($n=18$) or PCB-153 ($n=22$) throughout lifespan in chronic exposure study, plotted as $\text{mean}\pm \text{standard}\text{error}\text{of}\text{the}\text{mean}\left(\text{SEM}\right)$. **$p<0.01$; ***$p<0.001$ determined by Student’s t-test.