Figure 2.

Erythroid precursors, blood hemoglobin, and body weights of 4-wk-old wild-type (WT) and steroid and xenobiotic receptor knockout (SXRKO) mice perinatally exposed to polychlorinated biphenyl 153 (PCB-153) or vehicle. Representative fluorescence-activated cell sorter (FACS) plots of (A) bone marrow or (C) spleens of SXRKO mice exposed to dimethylsulfoxide (DMSO) and PCB-153, gating on erythroid precursors. Quantifications of erythroid precursors in (B) bone marrow and (D) spleens of 4-wk-old perinatally exposed mice (WT DMSO, $n=19$; WT PCB, $n=18$; SXRKO DMSO, $n=16$; SXRKO PCB, $n=13$) plotted as $\text{mean}\pm \text{standard}\text{error}\text{of}\text{the}\text{mean}\left(\text{SEM}\right)$. (E) Blood hemoglobin levels of WT and SXRKO mice at 4 wk of age perinatally exposed to either DMSO or PCB-153 ($n=5\text{per}\text{group}$) plotted as $\text{mean}\pm \text{SEM}$. (F) Body weights of exposed mice at 4 wk of age (WT DMSO, $n=19$; WT PCB, $n=18$; SXRKO DMSO, $n=16$; SXRKO PCB, $n=13$) plotted as $\text{mean}\pm \text{SEM}$. a, statistically significant compared to WT DMSO; b, statistically significant compared to WT PCB; c, statistically significant compared to SXRKO DMSO determined by two-way analysis of variance (ANOVA) and Tukey’s multiple-comparisons test.