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. 2020 Apr 30;128(4):047011. doi: 10.1289/EHP6262

Figure 7.

Figure 7A is a table, which in two columns titled DMSO and PCB-153, lists the fraction and percentage of intestinal tumors in the chronic PCB-153 exposure study mice groups indicated by three rows titled WT, hSXRki, and SXRKO. Figure 7B shows representative photographs of intestinal tumors found in SXRKO mice exposed to PCB-153. Figure 7C is a set of two representative FACS plots of the spleen of a non-tumor bearing SXRKO mouse on the left and a tumor-bearing SXRKO mouse exposed to PCB-153 on the right, plotting TER119 (y-axis) across CD71 (x-axis). Figure 7D is a graph, plotting percent erythroid precursors, ranging from 0, 1, 2, 3, 4, 5, 10, 40, and 70 (y-axis) across D, P, D, P, D, and P (x-axis) for WT, hSXRki, and SXRKO.

Prevalence and characterization of intestinal tumors in steroid and xenobiotic receptor knockout (SXRKO) mice chronically exposed to polychlorinated biphenyl 153 (PCB-153) until 10 months of age. (A) Number of intestinal tumors found in the upper intestine of 10-month-old wild-type (WT), SXRKO, and human SXR/pregnane X receptor (PXR) knock-in (hSXRki) mice chronically exposed to PCB-153 or dimethylsulfoxide (DMSO). (B) Representative images of the tumors (indicated by yellow arrowheads) located near the duodenum–jejunum junction of the upper intestine. (C) Representative fluorescence-activated cell sorter (FACS) plots of the spleen of a nontumor- vs. tumor-bearing mouse, gating on erythroid precursors. (D) Quantification of erythroid precursor percentage in the spleens of chronically exposed mice (WT DMSO, n=14; WT PCB, n=23; hSXRki DMSO, n=4; hSXRki PCB, n=4; SXRKO DMSO, n=22; SXRKO PCB, n=30) plotted as mean±standard error of the mean (SEM); tumor-bearing mice are indicated with yellow triangle symbols.