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. 2020 Apr 30;128(4):047011. doi: 10.1289/EHP6262

Figure 8.

Figure 8 illustrates the proposed mechanism for PCB-153 action on red blood cell oxidative stress and survival. On the left shows the wild type mouse with a liver that has normal metabolism and balanced oxidation-reduction, which leads to 3-OH-PCB-153 being successfully metabolized and cleared from the body leading to no RBC hemolysis. On the right shows the SXR knockout mouse with altered expression of CYPs and GSTs giving it altered metabolism and imbalanced oxidation-reduction in the liver leading to an accumulation of 3-OH-PCB-153 which then induces production of ROS and decreased GSH in RBCs leading to hemolysis.

Proposed mechanism of oxidative stress and anemia phenotype induced by polychlorinated biphenyl 153 (PCB-153) in steroid and xenobiotic receptor knockout (SXRKO) mice.