Table 2.

Liver transcriptome sequencing (RNA-seq) results.

	SXRKO DMSO vs. WT DMSO	SXRKO PCB vs. WT PCB	SXRKO PCB vs. SXRKO DMSO	WT PCB vs. WT DMSO
Total DEGs	260	394	60	0
Up-regulated	142	180	19	0
Down-regulated	118	214	41	0
GO terms (BPs)	47	103	9	0

Note: Number of total, up-regulated, and down-regulated differentially expressed genes (DEGs) for each comparison and the resulting number of significant gene ontology (GO) terms for biological processes (BPs). DEGs were determined by DESeq2 with $p\text{-adj}<0.05$ and absolute value of log2 $\left[\text{fold}\text{change}\left(\text{FC}\right)\right]>0.3$. GO term significance determined by Benjamini-Hochberg correction test ($p\text{-adj}<0.05$) in MouseMine (Mouse Genome Informatics 2019). DMSO, dimethylsulfoxide; PCB, polychlorinated biphenyl-153; SXRKO, steroid and xenobiotic receptor knockout (SXRKO); WT, wild-type.