Table 6.
Active combinatorial trials in gastrointestinal cancers.
| Trial ID | Cancer | PARP inhibitor | Immunotherapy | Phase |
|---|---|---|---|---|
| NCT02484404 | Colorectal | Olaparib | Atezolizumab (PD-L1) cediranib (VEGFR) | I/II |
| NCT02660034 | •HER2-negative gastric •Gastroesophageal junction •Advanced pancreatic | BGB-290 | BGB-A317 (PD-1) | I/II |
| NCT03851614 | •Advanced pancreatic •dMMR colorectal | Olaparib | Durvalumab (PD-1) | I/II |
| NCT03404960 | Advanced pancreatic | Niraparib | Nivolumab (PD-1) ipilimumab (CTLA-4) | I/II |
| NCT03637491 | Advanced pancreatic | Talazoparib | Avelumab (PD-1) | I/II |
| NCT02734004 | Relapsed gastric | Olaparib | Durvalumab (PD-L1) +/− bevacizumab | I/II |
| NCT03639935 | Biliary | Rucaparib | Nivolumab (PD-1) | II |