Table 3:

Regional gray matter volume reductions in patients with Angelman syndrome compared with controls based on voxel-based morphometry analysis^a

Anatomic Region	Number of Voxels in Each Cluster	Peak Z Score	Coordinates of Voxel of Maximal Statistical Significance (MNI Space)
Left putamen, pallidum, caudate nucleus	18,317	7.73	−21, 2, 12
Right caudate nucleus		7.68	9, 11, 15
Right putamen, pallidum		7.66	21, 5, 12
Right rectal gyrus	469	6.16	9, 34,−26
Right superior orbital gyrus
Left rectal gyrus
Left hippocampus	159	5.96	−20, −34, −0
Left thalamus
Left parahippocampal gyrus
Left lingual gyrus
Left cerebellum (Crus 1, 2)	156	5.95	−51, −48, −36
Left cerebellum (VII, VIII, crus 2)	47	5.67	−46, −43, −50
Left rectal gyrus	28	5.58	−6, 36, −30
Right rectal gyrus
Left superior orbital gyrus

^aWhole-brain analysis (FWE-corrected at P < .001; cluster threshold >20 voxels).