Table 1.

Amino acid polymorphism of the S1 protein among HeN‐2/China/2019, HeN‐101/China/2019 and other genotype IBV isolates

Position	IBV Strains				Location
	HeN−2/China/2019	HeN−101/China/2019	GI−19 genotype	Other genotypesc
87	La	P	P	P	RBD
89	Q	Kb	Q	S/N/T	RBD
96	S	Ab	S	S/N/K	RBD/HVRII
97	Q	Eb	Q	G/Q/K/E	RBD/HVRII
117	S	A	S	G/K/A/N	RBD/HVRII
120	T	Rb	T/S/A	H/A/Q/S	RBD/HVRII
130	A	E	A/P	P/E/Q/G	RBD/HVRII
131	R	S	R	Q/E/S/K	RBD/HVRII
195	A	S	A	A/S	—
300	Ia	T	T	T/I/S/V	HVRIII
315	Q	Hb	Q	R/S/D/G/T	HVRIII
329	Ya	H	H	H	HVRIII
511	I	Mb	I	I/V	—

Abbreviations: HVR, respected the hypervariable regions of S1 protein; RBD, respected the receptor‐binding domain of S1 protein.

^aSpecific amino acid mutation only found in HeN‐2/China/2019.

^bSpecific amino acid mutation only found in HeN‐101/China/2019.

^cThe major amino acids in the other genotypes IBV.