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TMPRSS2 gene transcription promoter site requires an activated androgen receptor, with androgens such as testosterone. Dihydrotestosterone (DHT) a potent androgen receptor activator and is intracellularly produced in particular cells of tissues such as prostate, hair, and liver that express 5‐alpha‐reductases, the targeted enzyme for drugs such as dutasteride and finasteride (5‐alpha‐reductase inhibitors)
