Table 1.
Cox regression analysis of OS
| Factor | Univariable analysis | Multivariable analysis: model I (n = 1045) | Multivariable analysis: model II (n = 753) | |||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Cases | HR | 95% CI | P | HR | 95% CI | P | HR | 95% CI | P | |
| homCD49d+* | 1522 | 3.18 | 2.41-4.19 | <.0001 | 2.13 | 1.52-2.99 | <.0001 | 2.65 | 1.76-3.98 | <.0001 |
| bimCD49d† | 1522 | 2.37 | 1.71-3.30 | <.0001 | 2.12 | 1.44-3.12 | .0001 | 2.70 | 1.74-4.17 | <.0001 |
| Age > 65 y | 1522 | 3.16 | 2.46-4.06 | <.0001 | 4.05 | 2.96-5.54 | <.0001 | 3.72 | 2.55-5.44 | <.0001 |
| Rai stage II-IV | 1515 | 2.68 | 2.10-3.43 | <.0001 | 1.82 | 1.32-2.44 | .0001 | n.i. | n.i. | n.i. |
| UM IGHV | 1385 | 3.88 | 3.02-5.00 | <.0001 | 2.41 | 1.79-3.24 | <.0001 | 2.78 | 1.99-3.91 | <.0001 |
| del17p | 1407 | 4.81 | 3.29-7.03 | <.0001 | n.i. | n.i. | n.i. | 2.21 | 1.44-3.38 | .0003 |
| del11q | 1407 | 2.56 | 177-3.69 | <.0001 | n.i. | n.i. | n.i. | n.i. | n.i. | n.i. |
| tri12 | 1407 | 1.82 | 1.29-2.56 | .0006 | 2.32 | 1.64-3.29 | <.0001 | 0.65 | 0.43-0.98 | .0423 |
| TP53 mutated | 1253 | 3.04 | 2.23-4.16 | <.0001 | 2.41 | 1.79-3.24 | <.0001 | n.i. | n.i. | n.i. |
| NOTCH1 mutated | 1444 | 2.02 | 1.54-2.65 | <.0001 | n.i. | n.i. | n.i. | n.i. | n.i. | n.i. |
| β2M > ULN | 1017 | 4.12 | 3.01-5.63 | <.0001 | — | — | — | 1.73 | 1.18-2.52 | .0048 |
All factors used in univariable analyses were entered in the multivariable analysis.
—, variable not included in the model; β2M, β-2 microglobulin; CI, confidence interval; del, deletion; HR, hazard ratio; n.i., not included in the model after stepwise selection; tri, trisomy; ULN, upper limit of normal; UM, unmutated.
*
homCD49d+ refers to CLL cases with ≥30% homogeneous expression of CD49d.
†
bimCD49d refers to CLL cases with bimodal expression of CD49d.