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Hydroxybupropion formation from RS-bupropion catalyzed by co-expressed CYP2B6 variants, wild-type P450 oxidoreductase and cytochrome b5. (●) S,S-hydroxybupropion from RS-bupropion, (○) R,R-hydroxybupropion from RS-bupropion. Results are the mean ± 95% confidence interval of triplicate determinations. Lines are predicted concentrations based on kinetic parameters obtained by nonlinear regression analysis of measured concentrations.
