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Metabolism of RS-bupropion catalyzed by coexpressed recombinant CYP2B6.1/POR variants/b5 at concentration of 2 µM RS-bupropion (1 µM R- or S-bupropion). Results are the mean ± 95% confidence interval of triplicate determinations. Asterisks denote rates significantly different from the wild-type POR (P < 0.001 for R-bupropion and P = 0.002 for S-bupropion). (A) R,R-hydroxybupropion formation from RS-bupropion. (B) S,S-hydroxybupropion formation from RS-bupropion.
