TABLE 3.
Summary of reported bupropion hydroxylation
Relative activities are shown as percentage of CYP2B6 variants Clint compared with the wild type (100 × Clint(variant)/Clint(wild type)).
| Reference | Zhang et al. (2011) | Xu et al. (2012) | Radloff et al. (2013) | This study | |
|---|---|---|---|---|---|
| Expression system | E. coli | Sf9 | COS-1 | T. ni | |
| RS | RS | RS | S,S | R,R | |
| CYP2B6.1 | 100 | 100 | 100 | 100 | 100 |
| CYP2B6.4 | 35 | 112 | 109 | ||
| CYP2B6.5 | 47 | 44 | 57 | 53 | |
| CYP2B6.6 | 43 | 65 | 81 | 51 | 34 |
| CYP2B6.7 | 79 | 34 | 22 | ||
| CYP2B6.9 | 38 | 27 | 20 | ||
| CYP2B6.17 | 72 | 114 | |||
| CYP2B6.19 | 45 | 46 | |||
| CYP2B6.26 | 52 | 49 | |||