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Sex and age affect trabecular bone of mice maintained on standard chow. Males and females of genotypes Nox4 fl/fl, PrxCre Nox4 fl/fl, and Nox4 0/0 at 13 and 32 weeks of age were analyzed. There were 5–12 mice per group. Three-way ANOVAs were conducted with sex, age, and genotype as the three factors. The panels indicate significant main effects and important interaction effects. (A–H) BMD, bone mineral density; Trab., trabecular; Vol., volume.
