Fig. 3.

Age, sex, and the Nox4 genotype affect cortical bone of mice maintained on standard chow. Males and females of genotypes Nox4 fl/fl, PrxCre Nox4 fl/fl, and Nox4 0/0 at 13 and 32 weeks of age were analyzed. There were 5–12 mice per group. Three-way ANOVAs were conducted with sex, age, and genotype as the three factors. The panels indicate significant main effects and important interaction effects. (A–E) BMD, bone mineral density;