Table 1.
Summary of measurements collected from HOME Study children and their mothers at 12 years of age (Cincinnati, Ohio, 2016–2018)
| Measurement category | Measurement or sample |
| Internalising symptoms and neurobehaviour | Anxiety |
| Depression | |
| Memory | |
| Fine motor skills | |
| Executive functions | |
| Social behaviours | |
| Social problem solving | |
| Problem behaviours (eg, attention-deficit/hyperactivity disorder) Adaptive behaviours | |
| Brain imaging | MRI Magnetic resonance spectroscopy Diffusion MRI |
| Functional MRI | |
| Body composition and bone health | Fat and lean mass, visceral fat mass |
| Whole body, lumbar spine, forearm, and hip bone mineral content and density | |
| Weight, height and waist/hip circumferences | |
| Cardiometabolic risk factors | Blood pressure |
| Heart rate | |
| Fasting insulin and glucose | |
| Fasting HDL, LDL, total cholesterol and triglycerides | |
| Leptin and adiponectin | |
| Central adiposity | |
| Biospecimens | Blood—serum and whole blood |
| Buccal cells | |
| Hair | |
| Stool | |
| Urine | |
| Shed deciduous teeth | |
| Chemical exposures | Phthalates, phenols, polybrominated diphenyl ether flame retardants, organophosphate flame retardants and perfluoroalkyl substances |
| Other biomarkers | High-resolution metabolomics |
| Leucocyte DNA methylation | |
| Vitamin D metabolites | |
| Urine drug screen | |
| Physical activity | Questionnaire |
| Accelerometer | |
| Diet | 3×24 hour Dietary recalls Eating behaviours |
| Sleep | Questionnaire |
| Actigraphy | |
| Pubertal development | Self-assessed Tanner staging Lutenising and follicle-stimulating hormones Estradiol, testosterone and dehydroepiandrosterone sulfate |
| Questionnaires | Substance Use |
| School Outcomes | |
| Sociodemographics | |
| Mother–Child Relationship | |
| Family Medical History | |
| Mother’s Mental Health and ADHD Symptoms | |
| Environmental Exposures |
ADHD, Attention-deficit/hyperactivity disorder; HDL, high-density lipoprotein; HOME, The Health Outcomes and Measures of the Environment; LDL, low-density lipoprotein.