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. 2020 May 5;5(1):e000462. doi: 10.1136/bmjophth-2020-000462

Figure 2.

Figure 2

Changes (in %) in Goldmann visual fields (GVF) (log) retinal areas from baseline, after 7 days of oral 9-cis-retinyl ester treatment in dominant RPE65 patients with late-onset retinitis pigmentosa (RP). Patient 10801. This patient aged 68 years shows an improvement in the size of the lll4e GVF area of ~200% and 150% in the R and L eyes after 10 months from baseline, and then a decline to ~45% from baseline at 1 year. The visual acuity (VA) did not change over this time period. The patient noted an ‘improvement in vision’ as a self-reported outcome (SRO). We deemed this patient to be a GVF responder. Patient 10802. This patient aged 68 years shows an improvement in the size of the lll4e area of the L eye only of 90% at 1 month and 70% at 7 months from baseline, and then a decline to baseline at 1 year. The R eye did not respond in this patient. The VA did not change over this time period. The patient noted an ‘improvement in vision’ as an SRO. We categorised this patient as a GVF responder. Patient 10803. This patient aged 67 years shows an improvement in the size of the ll4e GVF area of ~100% and ~70% in the R and L eyes after 7 months from baseline. After 10 months since baseline the ll4e GVF area declines to 40% in both eyes. The VA did not change over this time period. The patient did not experience an improvement on SRO. We concluded this patient is a GVF responder. Patient 10804. This patient aged 65 years shows no improvements in the sizes of the lll4e or the l4e (shown here) GVF areas in the R and L eyes from baseline. However, and importantly, the VA improved from 5 to 15 letters in one eye during the study period from baseline to 6 months (not shown). The patient did not experience an improvement on SRO. We noted that this patient is not a GVF responder but a VA responder. Patient 10805. This patient aged 41 years shows no improvements in the sizes of the lll4e and the l4e (shown here) GVF areas in the R and L eyes from baseline. The VA did not change over this time period. The patient did not experience an improvement on SRO. This patient is an example of a non-responder.